Powder For Solution For Infusion
Imipenem/Cilastatin Kabi is an intravenous broad spectrum beta-lactam antibiotic of the carbapenem class. Its bactericidal activity is against a broad spectrum of Gram-positive and Gram-negative bacteria, includin anaerobic pathogens.
Imipenem/Cilastatin Kabi is a combination of the antibiotic acting drug imipenem and the dehydropeptidase inhibitor cilastatin, which inhibits the imipenem degradation by the human enzyme dehydropeptidase. Cilastatin does not have own antibiotic activity.
20 ml clear glass vial x 10 in a carton box
Imipenem/Cilastatin Kabi is indicated for the treatment of the following infections in adults and children 1 year of age and above:
• Intra-abdominal infections
• Lower respiratory tract infections
• Gynecological infections
• Urinary tract infections
• Skin and soft-tissue infections
Treatment of patients with bacteraemia that occurs in association with, or is suspected to be associated with, any of the infections listed above. Consideration should be given to official guidance on the appropriate use of antibacterial agents.
Imipenem/Cilastatin Kabi is not indicated for the treatment of meningitis.
The daily dose of Imipenem/Cilastatin Kabi should be based on the type of infection and given in equally divided doses based on consideration of degree of susceptibility of the pathogen(s) and the patient’s renal function.
The usual dose for adults, based on a body weight of 70 kg is 1.5 to 2 g per day, given as 3 or 4 equal doses. The maximum dose is 50 mg per kg body weight per day. Not exceeding 4 g per day.
Dosing in children
Children weighing over 40 kg can be given the same Imipenem/Cilastatin dose as an adult children weighing less than 40 kg can be given 15 mg Imipenem/Cilastatin per kg body weight every 6 hours provided that they are at least 3 years old. The total daily dose in children should not be more than 60 mg per kg body weight and should not exceed a maximum of 2 g.
